We are currently seeking a talented and motivated person for a postdoctoral position in medically orientated mucosal research. The project will explore the development of female reproductive mucosal defence systems during pregnancy, with the goal of understanding how those systems contribute to reproductive health and the prevention of pre-term birth.
The candidate will join a recently established Wallenberg Centre for Molecular and Translational Medicine (WCMTM) at the University of Gothenburg (www.wcmtm.gu.se). As part of this venture, Dr. George Birchenough has recently established his research group (www.birchenoughlab.org) at the Department of Medical Biochemistry & Cell Biology at the University of Gothenburg and is now recruiting postdoctoral researchers and doctoral students. The group works towards a better understanding of how mucosal defence systems control our interactions with the environment, how those systems fail in disease and how they might be prophylactically or therapeutically targeted.
Subject area description
Our mucosal surfaces are the interface between the environment and our tissues. Their physiological functions are critical, but necessitate constant exposure of living cells to a vast collection of microbial lifeforms that includes many opportunistic and obligate pathogens. As a result, our mucosa have evolved multiple defensive systems that allow them to endure in this environment, and failure of these systems is often linked to development of acute and chronic disease. Consequently, understanding the development and regulation of these systems is key to understanding the pathoaetiology of mucosal disease and how they can be prevented or treated.
While much research has focused on the gastrointestinal and respiratory mucosal surfaces, the female reproductive system has gained relatively little attention. During pregnancy, the cervical mucosal epithelium undergoes dramatic alterations that include the appearance of large numbers of mucus secreting goblet cells. These cells generate a cervical mucus plug (CMP) that is thought to have an important role in preventing bacterial ascension from the vagina into the uterus during pregnancy. Crucially, both bacterial infection and altered CMP properties have been linked to the induction of pre-term birth, which is the largest single cause of neonatal mortality and results in approximately one million deaths per year worldwide.
By combining data from pre-clinical mouse models with analysis of samples from non-pregnant and pregnant humans, we hope to develop a better understanding of the mechanics of cervical goblet cell differentiation, CMP formation and the specific defensive roles of CMP proteins. This will in turn be used to determine how cervical defences might be augmented in order to prevent pre-term birth in humans.
The successful candidate will be expected to work extensively with pre-clinical mouse models in order to establish how cervical mucosal defences develop during pregnancy, and develop data that identifies their cellular and molecular basis. The candidate will be encouraged and expected to conduct their experimental research in an independent manner and to make significant contributions to project planning. The candidate will also actively contribute to the local research environment at the Mucin Biology Groups and engage in interactions with collaborators and other groups belonging to the WCMTM network. If necessary, the candidate may also be asked to assist in the supervision of Masters or PhD students.
An achieved doctoral degree is compulsory for a position as postdoctor at Göteborg University. The doctoral thesis shall be in a relevant area according to the specific position stated here. Since a position as postdoctor aims to give new holders of the doctorate the opportunity mainly to strengthen and develop their scholarly proficiency, we aim for those who have a doctoral degree not older than 3 years counting from last date of application.
Applications will be judged primarily on evidence of relevant scientific skills. The applicant must provide evidence of a PhD in a relevant area of research and have demonstrable skills in both written and spoken English. Previous experience working with animal models is essential. Expertise in microscopy, mass spectrometry, organoid culture, flow cytometry, microbiology, bioinformatics or in vivo disease modelling will be considered as strong merits in support of an application. Eligible applicants will be asked to partake in an interview and present their previous research. Great emphasis will be placed on the candidate’s personal suitability for the position and clear interest in the subject area.
The employment is full time and temporary, two years, with placement at the Institute of Biomedicine. First day of employment as agreed.
For further information:
Please contact George Birchenough: email – email@example.com; telephone – +46(0)317863046
In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.